Issue 1, 2021

The chemical biology of coronavirus host–cell interactions

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the current coronavirus disease 2019 (COVID-19) pandemic that has led to a global economic disruption and collapse. With several ongoing efforts to develop vaccines and treatments for COVID-19, understanding the molecular interaction between the coronavirus, host cells, and the immune system is critical for effective therapeutic interventions. Greater insight into these mechanisms will require the contribution and combination of multiple scientific disciplines including the techniques and strategies that have been successfully deployed by chemical biology to tease apart complex biological pathways. We highlight in this review well-established strategies and methods to study coronavirus–host biophysical interactions and discuss the impact chemical biology will have on understanding these interactions at the molecular level.

Graphical abstract: The chemical biology of coronavirus host–cell interactions

Article information

Article type
Review Article
Submitted
04 Nov. 2020
Accepted
06 Dec. 2020
First published
23 Dec. 2020
This article is Open Access
Creative Commons BY-NC license

RSC Chem. Biol., 2021,2, 30-46

The chemical biology of coronavirus host–cell interactions

S. Datta, E. C. Hett, K. A. Vora, D. J. Hazuda, R. C. Oslund, O. O. Fadeyi and A. Emili, RSC Chem. Biol., 2021, 2, 30 DOI: 10.1039/D0CB00197J

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements