Issue 40, 2020

Structural design and antimicrobial properties of polypeptides and saccharide–polypeptide conjugates

Abstract

The problems of microbial infections and the emergence of drug-resistant microbes are increasingly serious, causing countless loss of lives and economic loss. The discovery and study of host defense peptides opened a new avenue in developing antimicrobial regents, and have attracted a lot of attention in recent years. Compared with natural host defense peptides, synthetic antimicrobial polypeptides can be conveniently synthesized in large scale and with low cost. Furthermore, saccharide–polypeptide conjugates have been valued for their optimal effect on antimicrobial properties and biocompatibility. In this review article, we provide an overview of the development and progress of antimicrobial polypeptides and saccharide–polypeptide conjugates regarding their structural design, biological functions and antimicrobial mechanism. By pointing out the challenges, we also provide future prospects of this research field from our perspectives.

Graphical abstract: Structural design and antimicrobial properties of polypeptides and saccharide–polypeptide conjugates

Article information

Article type
Review Article
Submitted
08 Aug. 2020
Accepted
03 Sept. 2020
First published
09 Sept. 2020

J. Mater. Chem. B, 2020,8, 9173-9196

Structural design and antimicrobial properties of polypeptides and saccharide–polypeptide conjugates

Y. Wu, G. Xia, W. Zhang, K. Chen, Y. Bi, S. Liu, W. Zhang and R. Liu, J. Mater. Chem. B, 2020, 8, 9173 DOI: 10.1039/D0TB01916J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements