Issue 43, 2020

Biomedical application of mesoporous silica nanoparticles as delivery systems: a biological safety perspective

Abstract

The application of mesoporous silica nanoparticles (MSNs) as drug delivery systems to deliver drugs, proteins, and genes has expanded considerably in recent years, using in vitro and animal studies. For future translation to clinical applications, the biological safety aspects of MSNs must be considered carefully. This paper reviews the biosafety of MSNs, examining key issues such as biocompatibility, effects on immune cells and erythrocytes, biodistribution, biodegradation and clearance, and how these vary depending on the effects of the physical and chemical properties of MSNs such as particle size, porosity, morphology, surface charge, and chemical modifications. The future use of MSNs as a delivery system must extend beyond what has been learnt thus far using rodent animal models to encompass larger animals.

Graphical abstract: Biomedical application of mesoporous silica nanoparticles as delivery systems: a biological safety perspective

Article information

Article type
Review Article
Submitted
31 Jūl. 2020
Accepted
15 Sept. 2020
First published
15 Sept. 2020

J. Mater. Chem. B, 2020,8, 9863-9876

Biomedical application of mesoporous silica nanoparticles as delivery systems: a biological safety perspective

S. Hosseinpour, L. J. Walsh and C. Xu, J. Mater. Chem. B, 2020, 8, 9863 DOI: 10.1039/D0TB01868F

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