Issue 44, 2020

Time matters for macroscopic membranes formed by alginate and cationic β-sheet peptides

Abstract

Hierarchically ordered planar and spherical membranes (sacs) were constructed using amphiphilic and cationic β-sheet peptides that spontaneously assembled together with negatively charged alginate solution. The system was found to form either a fully developed membrane structure with three distinct regions including characteristic perpendicular fibers or a non-fully developed contact layer lacking these standing fibers, depending on the peptide age, membrane geometry and membrane incubation time. The morphological differences were found to strongly depend on fairly-long incubation time frames that influenced both the peptide's intrinsic alignment and the reaction–diffusion process taking place at the interface. A three-stage mechanism was suggested and key parameters affecting the development process were identified. Stability tests in biologically relevant buffers confirmed the suitability of these membranes for bio applications.

Graphical abstract: Time matters for macroscopic membranes formed by alginate and cationic β-sheet peptides

Supplementary files

Article information

Article type
Paper
Submitted
30 Jūn. 2020
Accepted
30 Jūl. 2020
First published
19 Aug. 2020

Soft Matter, 2020,16, 10132-10142

Time matters for macroscopic membranes formed by alginate and cationic β-sheet peptides

G. Yosefi, T. Levi, H. Rapaport and R. Bitton, Soft Matter, 2020, 16, 10132 DOI: 10.1039/D0SM01197E

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