Issue 5, 2020

Fluorogenic Trp(redBODIPY) cyclopeptide targeting keratin 1 for imaging of aggressive carcinomas

Abstract

Keratin 1 (KRT1) is overexpressed in squamous carcinomas and associated with aggressive pathologies in breast cancer. Herein we report the design and preparation of the first Trp-based red fluorogenic amino acid, which is synthetically accessible in a few steps and displays excellent photophysical properties, and its application in a minimally-disruptive labelling strategy to prepare a new fluorogenic cyclopeptide for imaging of KRT1+ cells in whole intact tumour tissues.

Graphical abstract: Fluorogenic Trp(redBODIPY) cyclopeptide targeting keratin 1 for imaging of aggressive carcinomas

Supplementary files

Article information

Article type
Edge Article
Submitted
01 Nov. 2019
Accepted
17 Dec. 2019
First published
18 Dec. 2019
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2020,11, 1368-1374

Fluorogenic Trp(redBODIPY) cyclopeptide targeting keratin 1 for imaging of aggressive carcinomas

R. Subiros-Funosas, V. C. L. Ho, N. D. Barth, L. Mendive-Tapia, M. Pappalardo, X. Barril, R. Ma, C. Zhang, B. Qian, M. Sintes, O. Ghashghaei, R. Lavilla and M. Vendrell, Chem. Sci., 2020, 11, 1368 DOI: 10.1039/C9SC05558D

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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