Issue 1, 2020

Is silver a mere terminal oxidant in palladium catalyzed C–H bond activation reactions?

Abstract

In the contemporary practice of palladium catalysis, a molecular understanding of the role of vital additives used in such reactions continues to remain rather vague. Herein, we disclose an intriguing and a potentially general role for one of the most commonly used silver salt additives, discovered through rigorous computational investigations on four diverse Pd-catalyzed C–H bond activation reactions involving sp2 aryl C–H bonds. The catalytic pathways of different reactions such as phosphorylation, arylation, alkynylation, and oxidative cycloaddition are analyzed, with and without the explicit inclusion of the silver additive in the respective transition states and intermediates. Our results indicate that the pivotal role of silver salts is likely to manifest in the form of a Pd–Ag heterobimetallic species that facilitates intermetallic electronic communication. The Pd–Ag interaction is found to provide a consistently lower energetic span as compared to an analogous pathway devoid of such interaction. Identification of a lower energy pathway as well as enhanced catalytic efficiency due to Pd–Ag interaction could have broad practical implications in the mechanism of transition metal catalysis and the current perceptions on the same.

Graphical abstract: Is silver a mere terminal oxidant in palladium catalyzed C–H bond activation reactions?

Supplementary files

Article information

Article type
Edge Article
Submitted
08 Sept. 2019
Accepted
30 Okt. 2019
First published
13 Nov. 2019
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2020,11, 208-216

Is silver a mere terminal oxidant in palladium catalyzed C–H bond activation reactions?

B. Bhaskararao, S. Singh, M. Anand, P. Verma, P. Prakash, A. C, S. Malakar, H. F. Schaefer and R. B. Sunoj, Chem. Sci., 2020, 11, 208 DOI: 10.1039/C9SC04540F

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