Issue 71, 2020

1-Phenyl-N-(benzothiazol-2-yl)methanimine derivatives as Middle East respiratory syndrome coronavirus inhibitors

Abstract

Middle East respiratory syndrome coronavirus (MERS-CoV) poses a serious threat to human health, and currently there are no effective or specific therapies available to treat it. Herein a series of 1-phenyl-N-(benzothiazol-2-yl)methanimine derivatives with inhibitory activity against MERS-CoV are described. The compound 4f with a 50% inhibition concentration value of 0.09 μM is a promising inhibitor that warrants further evaluation, towards the development of potential anti-MERS-CoV drugs.

Graphical abstract: 1-Phenyl-N-(benzothiazol-2-yl)methanimine derivatives as Middle East respiratory syndrome coronavirus inhibitors

Supplementary files

Article information

Article type
Paper
Submitted
03 Okt. 2020
Accepted
20 Nov. 2020
First published
07 Dec. 2020
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2020,10, 43299-43311

1-Phenyl-N-(benzothiazol-2-yl)methanimine derivatives as Middle East respiratory syndrome coronavirus inhibitors

M. Hu, H. Li, Y. Lin, Y. Zhang, J. Tang, J. Zuo, L. Yu, X. Tong, W. Tang and F. Yang, RSC Adv., 2020, 10, 43299 DOI: 10.1039/D0RA08442E

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