Issue 49, 2020

Copper-catalyzed synthesis of α-ketoamides using water and dioxygen as the oxygen source

Abstract

The reaction employing H2O and O2 as the co-oxygen source in the catalytic synthesis of α-ketoamides is described. This copper-catalyzed reaction is carried out in a tandem manner constituted by the hydroamination of alkyne, hydration of vinyl–Cu complex and subsequent oxidation. Isotope labeling and radical capture experiments reveal that the oxygen atom of α-ketone at α-ketoamides derives from O2 and the oxygen atom of amide group originates from H2O.

Graphical abstract: Copper-catalyzed synthesis of α-ketoamides using water and dioxygen as the oxygen source

Supplementary files

Article information

Article type
Paper
Submitted
07 Jūl. 2020
Accepted
27 Jūl. 2020
First published
06 Aug. 2020
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2020,10, 29114-29118

Copper-catalyzed synthesis of α-ketoamides using water and dioxygen as the oxygen source

Y. Xiao, Z. Yi, X. Yu and F. Xiao, RSC Adv., 2020, 10, 29114 DOI: 10.1039/D0RA05921H

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