Issue 26, 2020

A simple and cost-effective approach to fabricate tunable length polymeric microneedle patches for controllable transdermal drug delivery

Abstract

Polymeric microneedles (MNs) are attractive transdermal drug delivery systems because of their efficient drug delivery and minimal invasiveness. Master template fabrication is the most time-consuming and costly step in producing polymeric MNs using a micromoulding approach. Herein, this issue is addressed by modifying tattoo needle cartridges by adjusting the volume of a PDMS spacer, thus streamlining polymeric MN fabrication and significantly reducing its manufacturing cost. Using the fabricated master template, dissolvable polymeric MN systems containing poly(vinyl pyrrolidone) (PVP) and poly(vinyl alcohol) (PVA) were developed. This MN system exhibits several advantages, including controllable MN length, uniform distribution of each needle, and controllable drug release profiles. Overall, polymeric MN fabrication using this method is inexpensive, simple, and yields controllable and effective transdermal drug delivery.

Graphical abstract: A simple and cost-effective approach to fabricate tunable length polymeric microneedle patches for controllable transdermal drug delivery

Supplementary files

Article information

Article type
Paper
Submitted
12 Febr. 2020
Accepted
13 Apr. 2020
First published
20 Apr. 2020
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2020,10, 15541-15546

A simple and cost-effective approach to fabricate tunable length polymeric microneedle patches for controllable transdermal drug delivery

Y. Chen, Y. Xian, A. J. Carrier, B. Youden, M. Servos, S. Cui, T. Luan, S. Lin and X. Zhang, RSC Adv., 2020, 10, 15541 DOI: 10.1039/D0RA01382J

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