Issue 39, 2020

Enantioselective hydrophosphinylation of 1-alkenylphosphine oxides catalyzed by chiral strong Brønsted base

Abstract

A catalytic enantioselective addition of diarylphosphine oxides to 1-alkenyl(diaryl)phosphine oxides was achieved by using a chiral ureate as a chiral strong Brønsted base catalyst. The reaction followed by the reduction of phosphine oxide moieties provided chiral 1,2-diphosphinoalkanes, which are a family of useful chiral ligands for asymmetric transition metal catalysis.

Graphical abstract: Enantioselective hydrophosphinylation of 1-alkenylphosphine oxides catalyzed by chiral strong Brønsted base

Supplementary files

Article information

Article type
Communication
Submitted
27 Aug. 2020
Accepted
19 Sept. 2020
First published
21 Sept. 2020

Org. Biomol. Chem., 2020,18, 7814-7817

Enantioselective hydrophosphinylation of 1-alkenylphosphine oxides catalyzed by chiral strong Brønsted base

A. Kondoh, S. Ishikawa and M. Terada, Org. Biomol. Chem., 2020, 18, 7814 DOI: 10.1039/D0OB01778G

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