Issue 41, 2020

Deep eutectic solvent as solvent and catalyst: one-pot synthesis of 1,3-dinitropropanes via tandem Henry reaction/Michael addition

Abstract

The Henry reaction was performed using microwave heating within the deep eutectic solvent (DES) choline chloride/urea (ChCl/urea) which acted as both the catalyst and solvent for the reaction. The optimisation of the conditions (temperature, heating mode, time, DES) allowed 1,3-dinitropropane derivatives to be obtained via tandem Henry reaction/Michael addition, in one step from a range of different aromatic aldehydes in high yields and under mild reaction conditions.

Graphical abstract: Deep eutectic solvent as solvent and catalyst: one-pot synthesis of 1,3-dinitropropanes via tandem Henry reaction/Michael addition

Supplementary files

Article information

Article type
Paper
Submitted
23 Jūl. 2020
Accepted
20 Aug. 2020
First published
20 Aug. 2020

Org. Biomol. Chem., 2020,18, 8395-8401

Deep eutectic solvent as solvent and catalyst: one-pot synthesis of 1,3-dinitropropanes via tandem Henry reaction/Michael addition

G. Colombo Dugoni, A. Sacchetti and A. Mele, Org. Biomol. Chem., 2020, 18, 8395 DOI: 10.1039/D0OB01516D

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