Issue 1, 2020

A near infrared dye-coated silver nanoparticle/carbon dot nanocomposite for targeted tumor imaging and enhanced photodynamic therapy

Abstract

An excellent photosensitizer for imaging-guided high efficiency photodynamic therapy (PDT) requires certain features, such as near-infrared (NIR) light emission, high singlet-to-triplet intersystem crossing (ISC) efficiency, and tumor targeting. However, synthetizing photosensitizers that meet the aforementioned characteristics still remains a challenge. In this study, we synthetized a NIR dye (CyOH)–coated silver nanoparticle/carbon dot nanocomposite (CyOH–AgNP/CD) as a novel nanophotosensitizer for targeted tumor imaging and high-efficiency PDT. The CyOH–AgNP/CD nanophotosensitizer was constructed using a NIR dye (CyOH) and an AgNP/CD nanohybrid via Ag–O interaction. Relative to the AgNP/CD nanohybrid, CyOH–AgNP/CD exhibited a high singlet oxygen yield, mitochondrial accumulation, superior tissue penetration of 660 nm laser irradiation, and enhanced tumor targeting. The developed nanophotosensitizer exerted a higher antitumor effect than the CyOH dye or AgNP/CD nanohybrid. This result provides a new idea for the design of excellent photosensitizers that can benefit high-efficiency PDT.

Graphical abstract: A near infrared dye-coated silver nanoparticle/carbon dot nanocomposite for targeted tumor imaging and enhanced photodynamic therapy

Supplementary files

Article information

Article type
Paper
Submitted
20 Sept. 2019
Accepted
10 Dec. 2019
First published
11 Dec. 2019
This article is Open Access
Creative Commons BY-NC license

Nanoscale Adv., 2020,2, 489-494

A near infrared dye-coated silver nanoparticle/carbon dot nanocomposite for targeted tumor imaging and enhanced photodynamic therapy

R. Liu, Z. Yang, L. Zhang, J. Zhao, C. Hou and S. Zhao, Nanoscale Adv., 2020, 2, 489 DOI: 10.1039/C9NA00596J

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements