Issue 9, 2020

Triggered micropore-forming bioprinting of porous viscoelastic hydrogels

Abstract

Cell-laden scaffolds of architecture and mechanics that mimic those of the host tissues are important for a wide range of biomedical applications but remain challenging to bioprint. To address these challenges, we report a new method called triggered micropore-forming bioprinting. The approach can yield cell-laden scaffolds of defined architecture and interconnected pores over a range of sizes, encompassing that of many cell types. The viscoelasticity of the bioprinted scaffold can match that of biological tissues and be tuned independently of porosity and stiffness. The bioprinted scaffold also exhibits superior mechanical robustness despite high porosity. The bioprinting method and the resulting scaffolds support cell spreading, migration, and proliferation. The potential of the 3D bioprinting system is demonstrated for vocal fold tissue engineering and as an in vitro cancer model. Other possible applications are foreseen for tissue repair, regenerative medicine, organ-on-chip, drug screening, organ transplantation, and disease modeling.

Graphical abstract: Triggered micropore-forming bioprinting of porous viscoelastic hydrogels

Supplementary files

Article information

Article type
Communication
Submitted
17 Maijs 2020
Accepted
16 Jūl. 2020
First published
16 Jūl. 2020

Mater. Horiz., 2020,7, 2336-2347

Triggered micropore-forming bioprinting of porous viscoelastic hydrogels

G. Bao, T. Jiang, H. Ravanbakhsh, A. Reyes, Z. Ma, M. Strong, H. Wang, J. M. Kinsella, J. Li and L. Mongeau, Mater. Horiz., 2020, 7, 2336 DOI: 10.1039/D0MH00813C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements