Issue 9, 2020

Surface biofunctionalization to improve the efficacy of biomaterial substrates to be used in regenerative medicine

Abstract

Surface biofunctionalization has emerged in the past decade as a rising tool in Tissue Engineering and Regenerative Medicine (TERM) approaches. The development of biomaterial substrates with regenerative properties is challenging, mainly due to the requirement of obtaining a surface that promotes cell attachment, proliferation and differentiation. Biomolecules, namely extracellular matrix proteins and growth factors, play a key role in the wound healing cascade, mediating a wide range of cellular activities. Therefore, the immobilization of such biomolecules at the surface of biomaterials has a remarkable interest for TERM strategies. Numerous variants can be used to biofunctionalize the surface of biomaterials, being classified as non-covalent and covalent immobilization strategies. Importantly, the maintenance of stable/available bioactive factors needs also to be considered. In this review, a wide range of bioactive molecules and different biofunctionalization strategies will be discussed, as well as the most relevant results achieved in the novel and most promising strategies.

Graphical abstract: Surface biofunctionalization to improve the efficacy of biomaterial substrates to be used in regenerative medicine

Article information

Article type
Review Article
Submitted
31 Marts 2020
Accepted
26 Maijs 2020
First published
26 Maijs 2020

Mater. Horiz., 2020,7, 2258-2275

Surface biofunctionalization to improve the efficacy of biomaterial substrates to be used in regenerative medicine

M. R. Casanova, R. L. Reis, A. Martins and N. M. Neves, Mater. Horiz., 2020, 7, 2258 DOI: 10.1039/D0MH00542H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements