Issue 6, 2020

Acrylate–gelatin–carbonated hydroxyapatite (cHAP) composites for dental bone-tissue applications

Abstract

Various types of scaffolds made of synthetic polymers have been widely studied for bone-tissue applications due to their mechanical strength, biocompatibility and biodegradability, but the hydrophobic nature of synthetic polymers and frequent absence of pores within the scaffolds inhibit cellular attachment, infiltration, and tissue ingrowth. In this study, multi-composite scaffolds composed of dipentaerythritol hexa-acrylate (DPHA), ethylene glycol dimethacrylate (EGDMA), gelatin, and carbonated hydroxyapatite (cHAP) have been made. Percentage ratio of polymer matrix to gelatin was varied 50/50, 75/25, and 95/5 to change the porosity of the resultant scaffolds. The structure, crystallinity, and phase composition of the cHAP were confirmed by FTIR, Raman, XRD and Rietveld analyses, TG/DSC was used to evaluate the distribution of ceramics within the polymer matrix, and FTIR-ATR was used to confirm the molecular structure of composites. SEM/EDS analysis of the scaffolds revealed cavities and irregularities in the surface, and that cHAP was indistinctly exposed on the composite surface, computed tomography (CT) was used to estimate the density and homogeneity of the scaffolds, and the cHAP distribution within the scaffolds was evaluated by conventional radiography. The hydrophilicity of the multi-composite scaffolds was investigated using an aqueous solution of methylene blue dye which showed that the acrylate(75%)–gelatin(25%)–cHAP composite had the highest hydrophilicity. The results suggest that acrylate–gelatin–cHAP scaffolds have a potential for bone-tissue engineering.

Graphical abstract: Acrylate–gelatin–carbonated hydroxyapatite (cHAP) composites for dental bone-tissue applications

Article information

Article type
Paper
Submitted
10 Jūl. 2020
Accepted
24 Aug. 2020
First published
03 Sept. 2020
This article is Open Access
Creative Commons BY-NC license

Mater. Adv., 2020,1, 1675-1684

Acrylate–gelatin–carbonated hydroxyapatite (cHAP) composites for dental bone-tissue applications

R. Golubevas, Z. Stankeviciute, A. Zarkov, R. Golubevas, L. Hansson, R. Raudonis, A. Kareiva and E. Garskaite, Mater. Adv., 2020, 1, 1675 DOI: 10.1039/D0MA00498G

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements