Issue 31, 2020

Selective sensing of THC and related metabolites in biofluids by host:guest arrays

Abstract

A water-soluble host molecule can bind tetrahydrocannabinol (Δ9-THC) and its metabolites in aqueous solution. By pairing this recognition event in a sensing array with fluorescent reporters and varying external mediators, pattern recognition-based detection is possible, which allows selective discrimination of the THC metabolites. The selective sensing can be performed in aqueous solution with micromolar sensitivity, as well as in biofluids such as urine and saliva. Metabolites as similar as Δ8- and Δ9-THC, differing only in the position of a double bond, can be distinguished.

Graphical abstract: Selective sensing of THC and related metabolites in biofluids by host:guest arrays

Supplementary files

Article information

Article type
Communication
Submitted
25 Febr. 2020
Accepted
11 Marts 2020
First published
11 Marts 2020

Chem. Commun., 2020,56, 4352-4355

Author version available

Selective sensing of THC and related metabolites in biofluids by host:guest arrays

A. D. Gill, B. L. Hickey, W. Zhong and R. J. Hooley, Chem. Commun., 2020, 56, 4352 DOI: 10.1039/D0CC01489C

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