Issue 5, 2020

In vivo delivery of a fluorescent FPR2/ALX-targeted probe using focused ultrasound and microbubbles to image activated microglia

Abstract

To image activated microglia, a small-molecule FPR2/ALX-targeted fluorescent probe was locally delivered into the brain using focused ultrasound and microbubbles. The probe did not co-localise with neurons or astrocytes but accumulated in activated microglia, making this a potential imaging tool for future drug discovery programs focused on neurological disorders.

Graphical abstract: In vivo delivery of a fluorescent FPR2/ALX-targeted probe using focused ultrasound and microbubbles to image activated microglia

Supplementary files

Article information

Article type
Communication
Submitted
03 Aug. 2020
Accepted
11 Sept. 2020
First published
23 Sept. 2020
This article is Open Access
Creative Commons BY-NC license

RSC Chem. Biol., 2020,1, 385-389

In vivo delivery of a fluorescent FPR2/ALX-targeted probe using focused ultrasound and microbubbles to image activated microglia

S. V. Morse, T. Boltersdorf, T. G. Chan, F. N. E. Gavins, J. J. Choi and N. J. Long, RSC Chem. Biol., 2020, 1, 385 DOI: 10.1039/D0CB00140F

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