Issue 1, 2020

Dynamic visualization of type II peptidyl carrier protein recognition in pyoluteorin biosynthesis

Abstract

Using a covalent chemical probe and X-ray crystallography coupled to nuclear magnetic resonance data, we elucidated the dynamic molecular basis of protein recognition between the carrier protein and adenylation domain in pyoluteorin biosynthesis. These findings reveal a unique binding mode, which contrasts previously solved carrier protein and partner protein interfaces.

Graphical abstract: Dynamic visualization of type II peptidyl carrier protein recognition in pyoluteorin biosynthesis

Supplementary files

Article information

Article type
Communication
Submitted
27 Dec. 2019
Accepted
26 Febr. 2020
First published
24 Marts 2020
This article is Open Access
Creative Commons BY-NC license

RSC Chem. Biol., 2020,1, 8-12

Dynamic visualization of type II peptidyl carrier protein recognition in pyoluteorin biosynthesis

J. C. Corpuz, L. M. Podust, T. D. Davis, M. J. Jaremko and M. D. Burkart, RSC Chem. Biol., 2020, 1, 8 DOI: 10.1039/C9CB00015A

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