Issue 46, 2019

Single molecule sensing of amyloid-β aggregation by confined glass nanopores

Abstract

We have developed a glass nanopore based single molecule tool to investigate the dynamic oligomerization and aggregation process of Aβ1–42 peptides. The intrinsic differences in the molecular size and surface charge of amyloid aggregated states could be distinguished through single molecule induced characteristic current fluctuation. More importantly, our results reveal that the neurotoxic Aβ1–42 oligomer tends to adsorb onto the solid surface of nanopores, which may explain its instability and highly neurotoxic features.

Graphical abstract: Single molecule sensing of amyloid-β aggregation by confined glass nanopores

Supplementary files

Article information

Article type
Edge Article
Submitted
02 Jūl. 2019
Accepted
04 Okt. 2019
First published
08 Okt. 2019
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2019,10, 10728-10732

Single molecule sensing of amyloid-β aggregation by confined glass nanopores

R. Yu, S. Lu, S. Xu, Y. Li, Q. Xu, Y. Ying and Y. Long, Chem. Sci., 2019, 10, 10728 DOI: 10.1039/C9SC03260F

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