Issue 46, 2019

Tuning the Biginelli reaction mechanism by the ionic liquid effect: the combined role of supported heteropolyacid derivatives and acidic strength

Abstract

Herein, a combination of heteropolyacids and ionic liquids as a catalytic system was studied for the Biginelli multicomponent reaction; the positive ionic liquid effect associated with the acidic strength of zeolite-supported heteropolyacids made this combination an efficient catalytic system for the multicomponent synthesis of 3,4-dihydropyrimidin-2(1H)-one/thione derivatives. The acidic strength effect was evaluated, and a range was determined in which the reaction provided better results. The mechanism of the reaction was also investigated in the presence and absence of ionic liquids, and two features of paramount importance were revealed: the mechanism could be tuned to proceed through only one reaction path among three possibilities and the kinetics of the reaction was significantly faster in the presence of an ionic liquid.

Graphical abstract: Tuning the Biginelli reaction mechanism by the ionic liquid effect: the combined role of supported heteropolyacid derivatives and acidic strength

Supplementary files

Article information

Article type
Paper
Submitted
04 Maijs 2019
Accepted
02 Aug. 2019
First published
29 Aug. 2019
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2019,9, 27125-27135

Tuning the Biginelli reaction mechanism by the ionic liquid effect: the combined role of supported heteropolyacid derivatives and acidic strength

E. F. Freitas, R. Y. Souza, S. T. A. Passos, J. A. Dias, S. C. L. Dias and B. A. D. Neto, RSC Adv., 2019, 9, 27125 DOI: 10.1039/C9RA03336J

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