Issue 2, 2019

Biosynthesis of lagopodins in mushroom involves a complex network of oxidation reactions

Abstract

Use of the ku70-deficient strain of Coprinopsis cinerea enabled confirmation within the native context of the central role the sesquiterpene synthase Cop6 plays in lagopodin biosynthesis. Furthermore, yeast in vivo bioconversion and in vitro assays of two cytochrome P450 monooxygenases Cox1 and Cox2 allowed elucidation of the network of oxidation steps that build structural complexity onto the α-cuprenene framework during the biosynthesis of lagopodins. Three new compounds were identified as intermediates formed by the redox enzymes.

Graphical abstract: Biosynthesis of lagopodins in mushroom involves a complex network of oxidation reactions

Supplementary files

Article information

Article type
Communication
Submitted
12 Nov. 2018
Accepted
10 Dec. 2018
First published
10 Dec. 2018

Org. Biomol. Chem., 2019,17, 234-239

Biosynthesis of lagopodins in mushroom involves a complex network of oxidation reactions

T. Masuya, Y. Tsunematsu, Y. Hirayama, M. Sato, H. Noguchi, T. Nakazawa and K. Watanabe, Org. Biomol. Chem., 2019, 17, 234 DOI: 10.1039/C8OB02814A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements