Issue 7, 2019

Sialylated variants of lacto-N-tetraose exhibit antimicrobial activity against Group B Streptococcus

Abstract

Human milk oligosaccharides (HMOs) possess antimicrobial activity against a number of bacterial pathogens. HMOs prevent infection by serving as decoy receptors that competitively bind pathogens thus preventing pathogen attachment to host epithelial cell receptors. In a second mechanistic pathway, we recently demonstrated that heterogenous HMO extracts exert antimicrobial action against Group B Streptococcus by increasing cellular permeability. As human milk contains ca. 200 unique glycans however, our understanding of which pharmacophores are most important to HMO antimicrobial activity remains immature. In the present study, we describe the first evaluation of the antimicrobial and antibiofilm activities of five structurally defined, ubiquitous sialylated HMOs against Group B Streptococcus.

Graphical abstract: Sialylated variants of lacto-N-tetraose exhibit antimicrobial activity against Group B Streptococcus

Supplementary files

Article information

Article type
Paper
Submitted
24 Aug. 2018
Accepted
13 Sept. 2018
First published
13 Sept. 2018

Org. Biomol. Chem., 2019,17, 1893-1900

Sialylated variants of lacto-N-tetraose exhibit antimicrobial activity against Group B Streptococcus

K. M. Craft, H. C. Thomas and S. D. Townsend, Org. Biomol. Chem., 2019, 17, 1893 DOI: 10.1039/C8OB02080A

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