Issue 41, 2019

Hypoxia-induced biosynthesis of gold nanoparticles in the living brain

Abstract

While a large number of studies deal with biomedical applications of various types of nanoparticles synthesized using wet chemistry, we propose the concept of targeted biosynthesis of nanoparticles in the living brain. Here we demonstrate that the pathological biochemical process of accumulation of reduced pyridine nucleotides under deleterious conditions of brain hypoxia can be redirected to drive the biosynthesis of biocompatible Au nanoparticles from a precursor salt in situ in the immediate vicinity of the hypoxia site, thereby restoring the redox status of the brain.

Graphical abstract: Hypoxia-induced biosynthesis of gold nanoparticles in the living brain

Supplementary files

Article information

Article type
Communication
Submitted
09 Jūl. 2019
Accepted
01 Sept. 2019
First published
20 Sept. 2019

Nanoscale, 2019,11, 19285-19290

Author version available

Hypoxia-induced biosynthesis of gold nanoparticles in the living brain

E. A. Rozhkova, B. Lee, J. A. Prasad, Y. Liu and E. V. Shevchenko, Nanoscale, 2019, 11, 19285 DOI: 10.1039/C9NR05794C

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