Issue 11, 2019

Tuning the cationic interface of simple polydiacetylene micelles to improve siRNA delivery at the cellular level

Abstract

Polydiacetylene micelles were assembled from four different cationic amphiphiles and photopolymerized to reinforce their architecture. The produced micelles were systematically investigated, in interaction with siRNAs, for intracellular delivery of the silencing nucleic acids. The performances of the carrier systems were rationalized based on the cell penetrating properties of the micelles and the nature of their cationic complexing group, responsible for efficient siRNA binding and further endosomal escape.

Graphical abstract: Tuning the cationic interface of simple polydiacetylene micelles to improve siRNA delivery at the cellular level

Supplementary files

Article information

Article type
Paper
Submitted
09 Sept. 2019
Accepted
23 Sept. 2019
First published
24 Sept. 2019
This article is Open Access
Creative Commons BY license

Nanoscale Adv., 2019,1, 4331-4338

Tuning the cationic interface of simple polydiacetylene micelles to improve siRNA delivery at the cellular level

M. Hoang, M. Vandamme, G. Kratassiouk, G. Pinna, E. Gravel and E. Doris, Nanoscale Adv., 2019, 1, 4331 DOI: 10.1039/C9NA00571D

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