Issue 1, 2019

Dietary (−)-epicatechin affects NF-κB activation and NADPH oxidases in the kidney cortex of high-fructose-fed rats

Abstract

Inflammation involves the activation of redox-sensitive transcription factors, e.g., nuclear factor κB (NF-κB). Administration of (−)-epicatechin to high-fructose-fed rats prevented NF-κB activation and up-regulation of the NADPH oxidase 4 (NOX4) in the kidney cortex. These results add mechanistic insights into the action of (−)-epicatechin diminishing inflammatory responses.

Graphical abstract: Dietary (−)-epicatechin affects NF-κB activation and NADPH oxidases in the kidney cortex of high-fructose-fed rats

Article information

Article type
Communication
Submitted
13 Nov. 2018
Accepted
11 Dec. 2018
First published
03 Janv. 2019

Food Funct., 2019,10, 26-32

Dietary (−)-epicatechin affects NF-κB activation and NADPH oxidases in the kidney cortex of high-fructose-fed rats

P. D. Prince, C. Rodríguez Lanzi, C. G. Fraga and M. Galleano, Food Funct., 2019, 10, 26 DOI: 10.1039/C8FO02230E

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