Issue 13, 2019

New keys for old locks: carborane-containing drugs as platforms for mechanism-based therapies

Abstract

Icosahedral carboranes in medicine are still an emerging class of compounds with potential beneficial applications in drug design. These highly hydrophobic clusters are potential “new keys for old locks” which open up an exciting field of research for well-known, but challenging important therapeutic substrates, as demonstrated by the numerous examples discussed in this review.

Graphical abstract: New keys for old locks: carborane-containing drugs as platforms for mechanism-based therapies

Article information

Article type
Tutorial Review
Submitted
14 Marts 2019
First published
19 Jūn. 2019
This article is Open Access
Creative Commons BY-NC license

Chem. Soc. Rev., 2019,48, 3497-3512

New keys for old locks: carborane-containing drugs as platforms for mechanism-based therapies

P. Stockmann, M. Gozzi, R. Kuhnert, M. B. Sárosi and E. Hey-Hawkins, Chem. Soc. Rev., 2019, 48, 3497 DOI: 10.1039/C9CS00197B

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