Issue 13, 2019

Ball size or ball mass – what matters in organic mechanochemical synthesis?

Abstract

Ball mass is an important parameter that is known to have an influence on the outcome of a mechanochemical reaction induced by ball-milling. A standard way of modifying the ball mass is to change the size of the ball made of the same material. In this case, however, a change in mass is accompanied by a simulatneous change in the ball size. It is therefore not possible to disentangle the effects of mass and surface area in these cases. In the present work we report the results of experiments with specially designed and manufactured balls in which (1) milling ball mass is held constant, but their size differs, and (2) the ball mass is altered, with the diameter of the milling ball being held constant. Using the cocrystallisation of theophylline + nicotinamide as a case study it was found that both diameter and ball mass play crucial roles in determining the rate of a mechanochemical reaction. For comparison, we have also used milling balls with the same size (different mass), and others with the same mass (different size) made of different materials, as would be “traditional”. It was found that, despite having the same size, the lightest milling ball (nylon) was the most efficient in initiating the co-crystallisation, presumably due to the sorption of EtOH. Hence, the results of this manuscript also demonstrate how milling ball material can in fact be the most influential parameter, and potentially counterintuitive to classical mechanics.

Graphical abstract: Ball size or ball mass – what matters in organic mechanochemical synthesis?

Article information

Article type
Paper
Submitted
13 Dec. 2018
Accepted
16 Janv. 2019
First published
16 Janv. 2019
This article is Open Access
Creative Commons BY license

CrystEngComm, 2019,21, 2174-2179

Ball size or ball mass – what matters in organic mechanochemical synthesis?

A. A. L. Michalchuk, I. A. Tumanov and E. V. Boldyreva, CrystEngComm, 2019, 21, 2174 DOI: 10.1039/C8CE02109K

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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