Issue 59, 2019

Cu-Catalyzed highly selective reductive functionalization of 1,3-diene using H2O as a stoichiometric hydrogen atom donor

Abstract

A copper-catalyzed highly regio- and diastereo-selective reductive reaction of terminal 1,3-diene with water and aldehyde has been developed. This chemistry afforded a product containing a terminal alkenyl group, which is a versatile kind of precursor for organic synthesis, with the scope for various substrates. The present reaction system could realize the catalytic transfer of hydrogen to diene using water as a stoichiometric H atom donor. In this transformation, B2Pin2, a mild and practical kind of reductant was used as the mediator. The reaction pathway of this practical strategy was illustrated by a control experiment.

Graphical abstract: Cu-Catalyzed highly selective reductive functionalization of 1,3-diene using H2O as a stoichiometric hydrogen atom donor

Supplementary files

Article information

Article type
Communication
Submitted
24 Maijs 2019
Accepted
25 Jūn. 2019
First published
26 Jūn. 2019

Chem. Commun., 2019,55, 8651-8654

Cu-Catalyzed highly selective reductive functionalization of 1,3-diene using H2O as a stoichiometric hydrogen atom donor

Q. Li, X. Jiao, M. Xing, P. Zhang, Q. Zhao and C. Zhang, Chem. Commun., 2019, 55, 8651 DOI: 10.1039/C9CC04011K

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