Issue 52, 2019

Total synthesis and antimalarial activity of mortiamides A–D

Abstract

Mortiamides A–D (1–4) are head-to-tail cyclic heptapeptides that were identified from a novel Mortierella sp. isolate obtained from marine sediments from Northern Canada. Herein we report the first total synthesis of mortiamides A–D (1–4) on a solid support by concomitant cyclization/cleavage without any oligomerization side reactions, and overall yields up to 48%. We also report on the antiplasmodial activity of mortiamides A–D (1–4). We show that three out of the four tested mortiamides (A, B and D) have moderate antiplasmodial activity, while mortiamide D (4) exhibits low micromolar activity.

Graphical abstract: Total synthesis and antimalarial activity of mortiamides A–D

Supplementary files

Article information

Article type
Communication
Submitted
15 Apr. 2019
Accepted
18 Maijs 2019
First published
20 Maijs 2019

Chem. Commun., 2019,55, 7434-7437

Total synthesis and antimalarial activity of mortiamides A–D

C. Bérubé, D. Gagnon, A. Borgia, D. Richard and N. Voyer, Chem. Commun., 2019, 55, 7434 DOI: 10.1039/C9CC02864A

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