Issue 42, 2019

Pd-catalyzed synthesis of α,β-unsaturated ketones by carbonylation of vinyl triflates and nonaflates

Abstract

A general and highly chemoselective Pd-catalyzed protocol for the synthesis of α,β-unsaturated ketones by carbonylation of vinyl triflates and nonaflates is presented. Applying the specific monophosphine ligand cataCXium® A, the synthesis of various vinyl ketones as well as carbonylated natural product derivatives proceeds in good yields.

Graphical abstract: Pd-catalyzed synthesis of α,β-unsaturated ketones by carbonylation of vinyl triflates and nonaflates

Supplementary files

Article information

Article type
Communication
Submitted
20 Marts 2019
Accepted
24 Apr. 2019
First published
24 Apr. 2019

Chem. Commun., 2019,55, 5938-5941

Pd-catalyzed synthesis of α,β-unsaturated ketones by carbonylation of vinyl triflates and nonaflates

S. Zhang, H. Neumann and M. Beller, Chem. Commun., 2019, 55, 5938 DOI: 10.1039/C9CC02210D

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