Issue 12, 2019

A two-photon fluorescent probe for colorimetric and ratiometric monitoring of mercury in live cells and tissues

Abstract

Owing to the extreme toxicity of mercury, methods for its selective and sensitive sensing in solutions, and in live cells and tissues are in great demand. In this study, we developed a naphthalimide-based diphenylphosphinothioyl group-containing fluorescent and colorimetric probe that selectively detects mercury (Hg2+). Upon addition of mercury (Hg2+) to a solution of the probe, both a colorimetric change from colorless to yellow and a fluorescence change from blue to green (under a 365 nm hand-held UV lamp) occur, both of which can be observed using the “naked-eye”. Furthermore, the probe possesses the capability of sensing intracellular mercury in both live cells and tissues using dual-emission channels and two-photon microscopy.

Graphical abstract: A two-photon fluorescent probe for colorimetric and ratiometric monitoring of mercury in live cells and tissues

Supplementary files

Article information

Article type
Communication
Submitted
28 Okt. 2018
Accepted
14 Janv. 2019
First published
14 Janv. 2019

Chem. Commun., 2019,55, 1766-1769

A two-photon fluorescent probe for colorimetric and ratiometric monitoring of mercury in live cells and tissues

L. Chen, S. J. Park, D. Wu, H. M. Kim and J. Yoon, Chem. Commun., 2019, 55, 1766 DOI: 10.1039/C8CC08608G

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