Issue 6, 2019

The application of click chemistry for targeting quadruplex nucleic acids

Abstract

The Cu(I)-catalyzed azide and alkyne 1,3-dipolar cycloaddition (CuAAC), commonly known as the “click reaction”, has emerged as a powerful and versatile synthetic tool that finds a broad spectrum of applications in chemistry, biology and materials science. The efficiency, selectivity and versatility of the CuAAC reactions have enabled the preparation of vast arrays of triazole compounds with biological and pharmaceutical applications. In this feature article, we outline the applications and future prospects of click chemistry in the synthesis and development of small molecules that target G-quadruplex nucleic acids and show promising biological activities. Furthermore, this article highlights the template-assisted in situ click chemistry for developing G-quadruplex specific ligands and the use of click chemistry for enhancing drug specificity as well as designing imaging and sensor systems to elucidate the biological functions of G-quadruplex nucleic acids in live cells.

Graphical abstract: The application of click chemistry for targeting quadruplex nucleic acids

Article information

Article type
Feature Article
Submitted
03 Sept. 2018
Accepted
13 Nov. 2018
First published
29 Nov. 2018

Chem. Commun., 2019,55, 731-750

The application of click chemistry for targeting quadruplex nucleic acids

P. Saha, D. Panda and J. Dash, Chem. Commun., 2019, 55, 731 DOI: 10.1039/C8CC07107A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements