Issue 39, 2019

Investigation of cavitation-induced damage on PDMS films

Abstract

Traumatic brain injuries (TBIs) are complex phenomena that create epidemic healthcare and financial concerns. Recent studies have theorized that cavitation exists during a TBI and has potential to induce significant damage to the surrounding anatomy. This study seeks to implement polydimethylsiloxane (PDMS) films as a placeholder of the brain to elucidate the damage that the surrounding brain tissue would experience from nearby cavitation. The apparatus includes an existing methodology that implements controlled cavitation. 3D confocal microscopy and interferometry techniques are used to characterize the surface damage to the PDMS films. Visual representation and roughness parameters on the nanoscale help elucidate a distinct difference between control and experimental samples. These results help legitimize the concern of cavitation in the skull and also help motivate future studies to analyze the cellular response to surrounding cavitation.

Graphical abstract: Investigation of cavitation-induced damage on PDMS films

Article information

Article type
Paper
Submitted
24 Jūl. 2019
Accepted
29 Aug. 2019
First published
29 Aug. 2019
This article is Open Access
Creative Commons BY-NC license

Anal. Methods, 2019,11, 5038-5043

Investigation of cavitation-induced damage on PDMS films

A. H. Wrede, F. Al-Masri, R. Montazami and N. N. Hashemi, Anal. Methods, 2019, 11, 5038 DOI: 10.1039/C9AY01576K

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