Issue 47, 2018

A bio-inspired approach to ligand design: folding single-chain peptoids to chelate a multimetallic cluster

Abstract

Synthesis of biomimetic multimetallic clusters is sought after for applications such as efficient storage of solar energy and utilization of greenhouse gases. However, synthetic efforts are hampered by a dearth of ligands that are developed for multimetallic clusters due to current limitations in rational design and organic synthesis. Peptoids, a synthetic sequence-defined oligomer, enable a biomimetic strategy to rapidly synthesize and optimize large, multifunctional ligands by structural design and combinatorial screening. Here we discover peptoid oligomers (≤7 residues) that fold into a single conformation to provide unprecedented tetra- and hexadentate chelation by carboxylates to a [Co4O4] cubane cluster. The structures of peptoid-bound cubanes were determined by 2D NMR spectroscopy, and their structures reveal key steric and side-chain-to-main chain interactions that work in concert to rigidify the peptoid ligand. This efficient ligand design strategy holds promise for creating new scaffolds for the abiotic synthesis and manipulation of multimetallic clusters.

Graphical abstract: A bio-inspired approach to ligand design: folding single-chain peptoids to chelate a multimetallic cluster

Supplementary files

Article information

Article type
Edge Article
Submitted
24 Sept. 2018
Accepted
05 Nov. 2018
First published
15 Nov. 2018
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2018,9, 8806-8813

A bio-inspired approach to ligand design: folding single-chain peptoids to chelate a multimetallic cluster

A. I. Nguyen, R. K. Spencer, Christopher L. Anderson and R. N. Zuckermann, Chem. Sci., 2018, 9, 8806 DOI: 10.1039/C8SC04240C

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