Issue 2, 2018

Deformylation reaction-based probe for in vivo imaging of HOCl

Abstract

The detection of hypochlorous acid (HOCl) in vivo is vitally important because the local concentration of HOCl is highly correlated with some diseases such as atherosclerosis and rheumatoid arthritis. However, in vivo detection of HOCl remains a challenge due to the lack of a suitable probe. We report here a near-infrared (NIR) emissive “turn-on” probe (FDOCl-1) based on a methylene blue derivative, which can quickly detect HOCl via a newly found deformylation mechanism. FDOCl-1 displays remarkable selectivity and sensitivity towards HOCl. The dramatic changes in colour and NIR emission were used to detect HOCl in vitro and in vivo in a mouse arthritis model.

Graphical abstract: Deformylation reaction-based probe for in vivo imaging of HOCl

Supplementary files

Article information

Article type
Edge Article
Submitted
29 Aug. 2017
Accepted
01 Nov. 2017
First published
03 Nov. 2017
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2018,9, 495-501

Deformylation reaction-based probe for in vivo imaging of HOCl

P. Wei, W. Yuan, F. Xue, W. Zhou, R. Li, D. Zhang and T. Yi, Chem. Sci., 2018, 9, 495 DOI: 10.1039/C7SC03784H

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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