Issue 33, 2018

Functionalization of composite bacterial cellulose with C60 nanoparticles for wound dressing and cancer therapy

Abstract

A series of novel bacterial cellulose/C60 (BCC60) composites was prepared using a original dehydration-rehydration method. The composites were characterized to demonstrate their potential in multifunctional wound dressings for skin cancer treatment using photodynamic therapy. Raman spectroscopy revealed that the C60 nanoparticles were successfully incorporated into the bacterial cellulose (BC) network. Scanning electron microscopy was used to examine the morphology and distribution of the C60 particles as photosensitizers in the bacterial cellulose network, and the C60 particles were uniformly distributed in the hyperfine three-dimensional BC network with diameters less than 100 nm. Reactive oxygen species (ROS) measurements indicated that the BCC60 composites possessed a high ROS generation ability when exposed to light. The antibacterial assessment of the BCC60 composites revealed their ability to inhibit the growth of E. coli and S. aureus and their relationship with light irradiation. In vitro cell experiments also confirmed that the BCC60 composites had low cytotoxicity in the dark, while they exhibited significant cancer cell damage activity under visible light.

Graphical abstract: Functionalization of composite bacterial cellulose with C60 nanoparticles for wound dressing and cancer therapy

Supplementary files

Article information

Article type
Paper
Submitted
07 Janv. 2018
Accepted
09 Maijs 2018
First published
17 Maijs 2018
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2018,8, 18197-18203

Functionalization of composite bacterial cellulose with C60 nanoparticles for wound dressing and cancer therapy

M. Chu, H. Gao, S. Liu, L. Wang, Y. Jia, M. Gao, M. Wan, C. Xu and L. Ren, RSC Adv., 2018, 8, 18197 DOI: 10.1039/C8RA03965H

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