Issue 20, 2018

Enantioselective access to multi-cyclic α-amino phosphonates via carbene-catalyzed cycloaddition reactions between enals and six-membered cyclic imines

Abstract

A carbene-catalyzed enantioselective cycloaddition reaction between enals and cyclic ketiminophosphonates is disclosed. α-Amino phosphonates bearing sophisticated fused heterocycles and quaternary carbons are afforded with excellent enantioselectivities. The α-amino phosphonate products from our approach exhibit encouraging anti-bacterial activities against X. oryzae pv. oryzae, the bacteria that cause serious diseases to rice and other plants.

Graphical abstract: Enantioselective access to multi-cyclic α-amino phosphonates via carbene-catalyzed cycloaddition reactions between enals and six-membered cyclic imines

Supplementary files

Article information

Article type
Research Article
Submitted
14 Aug. 2018
Accepted
12 Sept. 2018
First published
13 Sept. 2018

Org. Chem. Front., 2018,5, 2992-2996

Enantioselective access to multi-cyclic α-amino phosphonates via carbene-catalyzed cycloaddition reactions between enals and six-membered cyclic imines

J. Sun, C. Mou, C. Liu, R. Huang, S. Zhang, P. Zheng and Y. R. Chi, Org. Chem. Front., 2018, 5, 2992 DOI: 10.1039/C8QO00877A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements