Issue 46, 2018

Photodeamination to quinone methides in cucurbit[n]urils: potential application in drug delivery

Abstract

We demonstrate a proof of principle for a new approach in the development of a drug delivery system. A positively charged prodrug (phenol) can form a stable inclusion complex with CB[7], which enables more efficient delivery of the prodrug. After photochemical transformation (photoactivation) inside the complex, an active drug quinone methide (QM) is formed and released from the complex, since it is a neutral molecule and forms a less stable complex with CB[7].

Graphical abstract: Photodeamination to quinone methides in cucurbit[n]urils: potential application in drug delivery

Supplementary files

Article information

Article type
Communication
Submitted
20 Okt. 2018
Accepted
05 Nov. 2018
First published
05 Nov. 2018

Org. Biomol. Chem., 2018,16, 8908-8912

Photodeamination to quinone methides in cucurbit[n]urils: potential application in drug delivery

Đ. Škalamera, M. Matković, L. Uzelac, M. Kralj, K. Mlinarić-Majerski, C. Bohne and N. Basarić, Org. Biomol. Chem., 2018, 16, 8908 DOI: 10.1039/C8OB02605J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements