Issue 27, 2018

Deletion of a global regulator LaeB leads to the discovery of novel polyketides in Aspergillus nidulans

Abstract

By disruption of LaeB, a global regulator recently characterized in Aspergillus nidulans, eight cryptic compounds in the mutant were identified, including seven polyketides and one NRPS-like product. Among the isolates, two phthalides and two dibenzo[1,4]dioxins are new compounds, revealing that the genetic manipulation of the global regulator represents a promising approach for the discovery of novel natural products in fungi.

Graphical abstract: Deletion of a global regulator LaeB leads to the discovery of novel polyketides in Aspergillus nidulans

  • This article is part of the themed collection: Biosynthesis

Supplementary files

Article information

Article type
Communication
Submitted
06 Jūn. 2018
Accepted
19 Jūn. 2018
First published
19 Jūn. 2018

Org. Biomol. Chem., 2018,16, 4973-4976

Deletion of a global regulator LaeB leads to the discovery of novel polyketides in Aspergillus nidulans

H. Lin, H. Lyu, S. Zhou, J. Yu, N. P. Keller, L. Chen and W. Yin, Org. Biomol. Chem., 2018, 16, 4973 DOI: 10.1039/C8OB01326H

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