Issue 4, 2018

Photodynamic therapy in 3D cancer models and the utilisation of nanodelivery systems

Abstract

Photodynamic therapy (PDT) is the subject of considerable research in experimental cancer models mainly for the treatment of solid cancerous tumours. Recent studies on the use of nanoparticles as photosensitiser carriers have demonstrated improved PDT efficacy in experimental cancer therapy. Experiments typically employ conventional monolayer cell culture but there is increasing interest in testing PDT using three dimensional (3D) cancer models. 3D cancer models can better mimic in vivo models than 2D cultures by for example enabling cancer cell interactions with a surrounding extracellular matrix which should enable the treatment to be optimised prior to in vivo studies. The aim of this review is to discuss recent research using PDT in different types of 3D cancer models, from spheroids to nano-fibrous scaffolds, using a range of photosensitisers on their own or incorporated in nanoparticles and nanodelivery systems.

Graphical abstract: Photodynamic therapy in 3D cancer models and the utilisation of nanodelivery systems

Article information

Article type
Minireview
Submitted
17 Okt. 2017
Accepted
15 Dec. 2017
First published
08 Janv. 2018
This article is Open Access
Creative Commons BY license

Nanoscale, 2018,10, 1570-1581

Photodynamic therapy in 3D cancer models and the utilisation of nanodelivery systems

L. Mohammad-Hadi, A. J. MacRobert, M. Loizidou and E. Yaghini, Nanoscale, 2018, 10, 1570 DOI: 10.1039/C7NR07739D

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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