Catalytic regeneration of a Th–H bond from a Th–O bond through a mild and chemoselective carbonyl hydroboration

Abstract

Here we present an unprecedented chemoselective hydroboration for aldehydes and ketones catalysed by actinides. The reaction features a very low catalyst loading (0.1–0.004 mol%) and quantitative product formation in less than 15 minutes, at room temperature. Thermodynamic and kinetic studies including stoichiometric and labeling studies with deuterated pinacolborane allow us to propose a plausible mechanism for this remarkable catalytic regeneration of a Th–H bond via carbonyl hydroboration.