Issue 48, 2018

Enantioselective total synthesis of sagittacin E and related natural products

Abstract

The first enantioselective total synthesis of eremophilane-type sesquiterpenoids, sagittacin E and related natural products, was achieved. This synthesis features an asymmetric desymmetrization by Shi asymmetric epoxidation, intramolecular aldol-type cyclization, allylic oxidation of a 1,4-diene compound, and stereoselective epoxidation.

Graphical abstract: Enantioselective total synthesis of sagittacin E and related natural products

Supplementary files

Article information

Article type
Communication
Submitted
27 Apr. 2018
Accepted
23 Maijs 2018
First published
29 Maijs 2018

Chem. Commun., 2018,54, 6165-6168

Enantioselective total synthesis of sagittacin E and related natural products

H. Abe, M. Fujimaki, E. Nakagawa, T. Kobayashi and H. Ito, Chem. Commun., 2018, 54, 6165 DOI: 10.1039/C8CC03438A

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