Issue 5, 2018

Control of tandem isomerizations: flow-assisted reactions of o-lithiated aryl benzyl ethers

Abstract

Tandem chemical changes are often difficult to control at will, because they proceed rapidly through multiple unstable reactive intermediates. It is desirable to develop a novel method for controlling such tandem changes to obtain desired products with high selectivity. Herein, we report a flow microreactor platform for controlling tandem isomerizations of o-lithiated aryl benzyl ethers based on precise residence time control.

Graphical abstract: Control of tandem isomerizations: flow-assisted reactions of o-lithiated aryl benzyl ethers

Supplementary files

Article information

Article type
Communication
Submitted
03 Nov. 2017
Accepted
19 Dec. 2017
First published
19 Dec. 2017

Chem. Commun., 2018,54, 547-550

Control of tandem isomerizations: flow-assisted reactions of o-lithiated aryl benzyl ethers

H. Lee, H. Kim, J. Yoshida and D. Kim, Chem. Commun., 2018, 54, 547 DOI: 10.1039/C7CC08460A

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