Issue 32, 2017

Material chemistry of graphene oxide-based nanocomposites for theranostic nanomedicine

Abstract

The promising biomedical applications of graphene oxide (GO) have quickly catalyzed a generation of various GO-based functional composites with desirable nanostructures and composites to satisfy the specific biomedical applications of GO-based nanosystems. This comprehensive review summarizes and discusses the very recent developments in rational design, chemical fabrication and versatile biomedical applications of GO-based functional composites, including metal oxide–GO, metal–GO, fluorescent nanoparticles–GO, silica–GO, polymer–GO and other specific GO-based composite nanosystems. The integration of multi-components with GO is also discussed. Their versatile theranostic applications include diagnostic imaging-guided therapy (photothermal therapy, photodynamic therapy and chemotherapy), biosensing-based tumor detection, and synergistic therapy. The biocompatibility and biosafety of these promising GO-based nanocomposites are also briefly mentioned. Finally, the unresolved critical issues and challenges facing the design/fabrication/application of these unique GO-based functional nanocomposites are proposed to further promote their clinical translation. The unique multi-composition, nanostructure and unique theranostic performance of GO-based composites are highly expected to pave a new way for the development of highly efficient theranostic protocols/approaches for precise personalized biomedicine to benefit human health.

Graphical abstract: Material chemistry of graphene oxide-based nanocomposites for theranostic nanomedicine

Article information

Article type
Review Article
Submitted
11 Marts 2017
Accepted
27 Apr. 2017
First published
27 Apr. 2017

J. Mater. Chem. B, 2017,5, 6451-6470

Material chemistry of graphene oxide-based nanocomposites for theranostic nanomedicine

Y. Zhou, X. Jing and Y. Chen, J. Mater. Chem. B, 2017, 5, 6451 DOI: 10.1039/C7TB00680B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements