Issue 5, 2017

Manganese-catalyzed allylation via sequential C–H and C–C/C–Het bond activation

Abstract

Manganese-catalyzed sequential C–H and C–C/C–Het bond activation to synthesize allylic alcohols, allylated arenes, functionalized cyclopentenes and skipped dienes is reported. This protocol can be readily scaled up and various coupling partners are applied in manganese catalysis for the first time. Moreover, manganese-catalyzed alkenyl C(sp2)–H activation is also shown. Complimentary to the standard solution-based protocols, these reactions also proceed efficiently under neat conditions, which is unprecedented for abundant metal catalyzed C–H activation reactions.

Graphical abstract: Manganese-catalyzed allylation via sequential C–H and C–C/C–Het bond activation

Supplementary files

Article information

Article type
Edge Article
Submitted
16 Janv. 2017
Accepted
24 Febr. 2017
First published
24 Febr. 2017
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2017,8, 3379-3383

Manganese-catalyzed allylation via sequential C–H and C–C/C–Het bond activation

Q. Lu, F. J. R. Klauck and F. Glorius, Chem. Sci., 2017, 8, 3379 DOI: 10.1039/C7SC00230K

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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