Issue 83, 2017

Value of mir-247 in warning of graphene oxide toxicity in nematode Caenorhabditis elegans

Abstract

Graphene oxide (GO) induces some dysregulated microRNAs (miRNAs), such as mir-247, in Caenorhabditis elegans. We here further investigated the role and value of mir-247 in detecting GO toxicity in nematodes after prolonged exposure. In nematodes, mir-247 acted in neurons to regulate GO toxicity, and neuronal overexpression of mir-247 induced a susceptibility to GO toxicity. We detected the significant increase in mir-247 in wild-type nematodes exposed to GO at concentrations of more than 10 μg L−1. Moreover, we found the GO toxicity in a transgenic strain overexpressing neuronal mir-247 after exposure to GO at concentrations of more than 10 μg L−1. Therefore, our results imply the important potential of mir-247 in warning of the formation of GO toxicity in the range of μg L−1 in nematodes.

Graphical abstract: Value of mir-247 in warning of graphene oxide toxicity in nematode Caenorhabditis elegans

Supplementary files

Article information

Article type
Paper
Submitted
17 Aug. 2017
Accepted
03 Nov. 2017
First published
14 Nov. 2017
This article is Open Access
Creative Commons BY license

RSC Adv., 2017,7, 52694-52701

Value of mir-247 in warning of graphene oxide toxicity in nematode Caenorhabditis elegans

G. Xiao, L. Zhi, X. Ding, Q. Rui and D. Wang, RSC Adv., 2017, 7, 52694 DOI: 10.1039/C7RA09100A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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