Issue 60, 2017

Effect of metal–metal distance in Ni(ii)-based metallo-supramolecular polymers: DNA binding and cytotoxicity

Abstract

Two Ni(II)-based metallo-supramolecular polymers (polyNiL1 and polyNiL2) with different metal–metal distances were synthesized via (1 : 1) complexation between the Ni salts with bis(1,10-phenanthroline)s and their DNA binding properties and cytotoxicity were revealed. Short metal–metal distances (1.35 nm) in polyNiL2 showed ∼7 times stronger DNA binding properties and remarkably higher cytotoxicity to Hela-Fucci cells than long metal–metal distances (1.95 nm) in polyNiL1. Enhancement of Ni polymer-induced cell killing has been observed in a cell cycle study.

Graphical abstract: Effect of metal–metal distance in Ni(ii)-based metallo-supramolecular polymers: DNA binding and cytotoxicity

Supplementary files

Article information

Article type
Paper
Submitted
19 Maijs 2017
Accepted
25 Jūl. 2017
First published
02 Aug. 2017
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2017,7, 38008-38013

Effect of metal–metal distance in Ni(II)-based metallo-supramolecular polymers: DNA binding and cytotoxicity

Md. D. Hossain, U. Rana, C. Chakraborty, J. Li, R. Nagano, T. Minowa and M. Higuchi, RSC Adv., 2017, 7, 38008 DOI: 10.1039/C7RA05644C

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