Issue 59, 2017

The value of pyrans as anticancer scaffolds in medicinal chemistry

Abstract

Pyran is an oxygen-containing heterocyclic moiety, which exhibits an array of pharmacological properties. Pyran is also one of the important structural subunits found widely in natural products, e.g. coumarins, benzopyrans, sugars, flavonoids, xanthones, etc. The diverse anticancer capabilities of pyrans have been additionally evidenced by the fact that this heterocycle has recently been a focal point for researchers worldwide. This review provides a summary of pyran-based anticancer compounds, with emphasis on the past 10 years. It focuses on advancements in the field of naturally occurring pyrans as anticancer agents. The discussion also includes structure–activity relationships, along with the structures of the most promising molecules, their biological activities against several human cancer cell lines, as well as mechanistic insights discovered through the pharmacological evaluation and molecular modeling of pyran-based molecules. The promising activities revealed by these pyran-based scaffolds undoubtedly place them at the forefront for the discovery of prospective drug candidates. Thus, they could therefore be of great interest to researchers working on the synthesis of antitumour drug candidates.

Graphical abstract: The value of pyrans as anticancer scaffolds in medicinal chemistry

Supplementary files

Article information

Article type
Review Article
Submitted
14 Maijs 2017
Accepted
17 Jūl. 2017
First published
25 Jūl. 2017
This article is Open Access
Creative Commons BY license

RSC Adv., 2017,7, 36977-36999

The value of pyrans as anticancer scaffolds in medicinal chemistry

D. Kumar, P. Sharma, H. Singh, K. Nepali, G. K. Gupta, S. K. Jain and F. Ntie-Kang, RSC Adv., 2017, 7, 36977 DOI: 10.1039/C7RA05441F

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements