Issue 51, 2017

Progress and perspectives in bioactive agent delivery via electrospun vascular grafts

Abstract

The review discusses the progress in the design and synthesis of bioactive agents incorporated into vascular grafts obtained by the electrospinning process. Electrospun fibers can be applied as an artificial extracellular matrix for tissue engineering and drug delivery, improving tissue regeneration and therapeutic outcomes. A large number of active substances are loaded into the fibers, such as growth factors, heparin, NO donors, statins, antibiotics or anti-inflammatory agents. There are various methods for bioactive substance incorporation including direct blending, emulsion, and coaxial electrospinning as well as covalent and non-covalent binding of the bioactive molecules to the fiber surface. The release mechanism of the drug depends on the synthesis route, active substance properties, and polymer matrix nature. The electrospun materials represent a very promising building block for the fabrication of effective vascular prosthesis in the near future.

Graphical abstract: Progress and perspectives in bioactive agent delivery via electrospun vascular grafts

Article information

Article type
Review Article
Submitted
27 Apr. 2017
Accepted
08 Jūn. 2017
First published
23 Jūn. 2017
This article is Open Access
Creative Commons BY license

RSC Adv., 2017,7, 32164-32184

Progress and perspectives in bioactive agent delivery via electrospun vascular grafts

M. Rychter, A. Baranowska-Korczyc and J. Lulek, RSC Adv., 2017, 7, 32164 DOI: 10.1039/C7RA04735E

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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