Catalytic asymmetric synthesis of hetero-substituted oxindoles

Abstract

Chiral disubstituted oxindoles represent an important family of bioactive molecules. The construction of asymmetric quaternary carbon in the cyclopentane ring is therefore a challenging problem for organic chemists. In the last few years, many papers have appeared on asymmetric catalytic methods for the synthesis of these compounds and the literature on spirocyclic derivatives, 3-substituted-3-hydroxyoxindoles and 3-substituted-3-aminooxindoles has been largely reviewed. The literature on other hetero-substituted oxindoles has not been fully reviewed after 2011. This review aims to fill this gap by covering the literature on these topics until the end of 2016. A special section is also devoted to indoline-thiones.